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The ongoing Stockholm III trial – which is randomising between three arms: SCPRT proceeding to immediate surgery within a week, SCPRT and delayed surgery after 4 8 weeks, and 50 Gy in 25 fractions with surgery after a similar interval [57] – will also provide additional information on allowing an interval for response after SCPRT.
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The fact that we detected a RIN4 ortholog in a novel interval for responses to two of the three pathogenesis factors targeting RIN4 suggests the intriguing possibility of natural variation in a guardee contributing to pathogen resistance, similar to what has been observed for the tomato guardee RCR3 (Hörger et al., 2012).
To address these limitations a Bayesian method of determining credible intervals for response surface optima was developed.
Confidence intervals for response rates were calculated with Agresti and Coull's method [30].
Ninety-five perconfidencedence intervals for response rates were calculated.
Confidence intervals for response rates were calculated using the Clopper Pearson method.
TTP and OS were estimated by the Kaplan-Meier method [ 15], and the confidence intervals for response rates were calculated using methods for exact binomial confidence intervals [ 16].
The 95% exact confidence interval (CI) for response was calculated.
The 95% confidence interval (CI) for response and clinical benefit was calculated.
The response time (t res) is the time interval for the response to rise from 10to90%0% of the total current change.
The confidence interval for each response was 95% in the mentioned ranges on the plots.
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