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Interval antibiotic therapy is associated with the presence of MDR bacteria.
CNS, coagulase negative staphylococci; IA, interval antibiotic therapy; PP, postoperative peritonitis; * P < 0.05 vs group without broad-spectrum IA.
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Two-stage total hip arthroplasty (THA) with an interval antibiotic-loaded polymethylmetacrylate spacer has been recently proposed to clear infection and improve hip function after septic hip arthritis [ 7- 9].
Interval antibiotics (IA) were defined as antimicrobial agents administered between S0 and reoperation, at during at least 24 hours and started at least 24 hours before reoperation.
By altering the interval between antibiotic treatments, and the dosage of antibiotic, we show that different treatment regimes can select for either plasmid-carried, or chromosome-carried, resistance.
Timing of CT: The most common reason for CT failure in diagnosing CD is an excessively long interval between antibiotic therapy initiation and CT [5].
In our series where bone transport was performed after resection for infection, we inserted the intramedullary nails after an interval of antibiotic therapy.
The median interval between antibiotic administration and delivery was nine hours (range 0 – 36 hours).
For β-lactams, old philosophies are being revisited to increase the duration of the dosing interval that antibiotic concentrations exceed the MIC.
Four patients had more than one strain collected: two patients had two separate infectious episodes each caused by different strains; 1 patient was colonized with one strain and subsequently infected with this strain and in the last patient, the same strain was retrieved at a 1 week interval despite antibiotics.
Consecutive co-transfections were performed at 48 hr intervals in antibiotic free media.
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