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For example, chromosomal "loopings" are pivotal for the orderly process of gene expression, by enabling distal regulatory enhancer or silencer elements to directly interact with proximal promoter and transcription start sites, potentially bypassing hundreds of kilobases of interspersed sequence on the linear genome.
L1 sequences are highly repetitive interspersed sequence, an estimated 100,000 L1 elements are present in the entire human genome.
Compared with current measurements based on contiguous sequence similarity in local or global alignments, this new measurement considers interspersed sequence similarity.
The high specificity of ORF2 reverse transcriptase activity may explain the lack of other nonautonomous elements, including short interspersed sequence elements and pseudogenes in the chicken genome (International Chicken Genome Sequencing Consortium 2004).
Among PSSM approaches, BioProspector was selected, since, unlike most of PSS algorithms, it features high-order Markov models, which allows one to discover longer and more interspersed sequence motifs [ 31].
However, precise deletion of the two copies of PfM18.1 and interspersed sequence the PfM18.1 at 588 base pairs upstream of the RAP3 start codon abolished of distinct stage-specific expression pattern demonstrating PfM18.1 is essential for proper control of transcript levels.
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Long INterspersed Element-1s (LINE-1s) are retrotransposons with highly repetitive, interspersed sequences which are distributed randomly throughout the genome, and constituting 17% of the total human genome [ 24, 25].
The sequencing of the Teqing BAC contig in the SUB1 region confirmed the presence of ∼50% interspersed sequences of transposon or retrotransposon origin (Xu et al. 2006).
Imports can be interrupted by interspersed sequences of the recipient (ISR) of varying length which can accelerate allelic diversification.
The three-step approach provided us with a set of de novo consensus sequences corresponding to interspersed sequences occurring at least three times in the genome studied.
In about 10% of recombinant clones, the imported fragments of donor DNA were interrupted by short interspersed sequences of the recipient (ISR) with a mean length of 82 bp.
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