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BAC VV40024H127M19 showed a tandem-duplication signal, whereas the others showed an interspersed pattern.
Despite this interspersed pattern, inside cells cenH3 and H3 nucleosomes occupy physically distinct regions in space (Blower et al. 2002; Zhang et al. 2005).
Alu (SINE) elements appear to be the predominant repeat sequences at junctions in primates where they contribute to the interspersed pattern of gene duplication characterizing the human genome [ 15, 17].
These higher order repeats arose by amplification of the mutated repeats present in proximal telomeric regions and the interspersed pattern developed by further amplifications of the 5-bp repeat arrays together with higher order repeat arrays.
We expressed this construct in HeLa 1C7 cells that maintain a single copy of the HAC, display conservation of the HAC centromere-associated chromatin signature (including the interspersed pattern of H3K4me2 and H3K36me2 nucleosomes on kinetochore fibres) and show a similar HAC mitotic stability to the original HT1080 cells (Cardinale et al (2009) and data not shown).
Despite the overall interspersed pattern of clustering of first trimester samples of various gestations (8 - 12 weeks), we tested to see whether any genomic regions undergo selective changes in methylation during the transition from early first trimester to late first/early second trimester.
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This examination revealed that the hypervariable loci in these strains have highly heterogeneous gene content with conserved and absent/divergent genes interspersed, a pattern that is consistent with our microarray-CGH data.
To prevent the birds from responding to the noise pattern per se, we interspersed a noise pattern equal to that in the noise motif (i.e., only the noise of this stimulus without any motif parts) with a probability of 20% between the repeated background sounds and not overlapping with the motif modifications.
The garden's terracing and walls interweave, forming a wave pattern, interspersed with rocks bearing carved Maya faces.
In a root and pattern system, the basic meaning of the word is expressed by its consonants (the "root"), while a sequence of vowels (the "pattern") interspersed in the consonantal skeleton adds grammatical information or modifies the basic lexical meaning of the root.
The fibrous tissue of the hernia sac was closed with 2 polydioxanone (PDS II; Ethicon, Bridgewater, NJ) in a horizontal mattress pattern, interspersed with simple interrupted followed by simple interrupted tacking sutures using 0 poliglecaprone 25 (Monocryl Plus; Ethicon, Bridgewater, NJ), which were placed through the hernia sac and subcutaneous tissue to reduce dead space.
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