What will validation validate?
However, the inspection showed that the results are very unstable, as reflected in the huge variation of subsets cardinality among the cross-validation folds and small intersection of these subsets.
First, the validation rate of WGS-WES intersection INDELs was in fact very high (95%), indicating INDELs called from both WGS and WES data were mostly true-positives (Table 3).
While GRACOMICS cannot give conclusive evidence that the highlighted markers are significant, it can help the biologist narrow down the candidate list, based on the intersection of markers for efficiency for further validations, such as RT-PCR.
I outline four reasons why bioinformaticians are newly enabled to drive the questions in primary medical discovery: public availability of data, intersection of data across experiments, commoditization of methods, and streamlined validation.
Additionally, the validation has two implicit subtypes, which are determined by the intersection with the training set (of Compounds).
Additionally, since lower exCNV counts were shown by the intersection of ExomeCopy and ExCopyDepth, these results were also used for experimental validation.
In studies involving WES or WGS of familial PD, rare variants can be prioritized for validation and replication in additional samples by looking at the intersection of those shared by affected family members and not shared by elderly unaffected relatives.
For validation the model, the real capacities at the same intersections are measured for saturated cycles where the capacity can be considers as the measured volume.
Therefore, we have validation data on 160, 145, and 161 loci from the WGS-WES intersection, WGS-specific, and WES-specific INDELs, respectively.
