We compare intersecting gene expression profiles following separate PAR2 activation by a peptide (2f-LIGRLO-NH2) versus a serine protease (trypsin), expecting that genes up- or down- regulated by both agents might help identify cellular pathways associated with PAR2 activation.
However, when intersecting the expression (two-fold change with an FDR < 0.05) and methylation (555 DMPs) significant gene lists, there was no significant overlap.
Recent sequencing of additional T. gondii isolates identifies >620 K new SNPs, including ~11 K that intersect with expression profiling probes, yielding additional markers for genotyping studies, and further validating the utility of a combined expression profiling/genotyping array design.
This split-intein-split-Cre system can be used to intersect the expression patterns of two genes or promoters to restrict full-length Cre reconstitution in their overlapping domains.
These studies successfully intersected gene expression profiles with independently obtained GWAS results to provide further support for previously identified candidate loci.
As a final view, gene expression differences identified between embryonic stages with amplified samples were both reliable (tiny intersect with deviating expressions) and relevant (biologically valid).
In summary, by intersecting the results of expression profiling following a FOXO1a knockdown, computational analyses and PCR amplification of ChIP enriched promoter regions, we identified eight novel direct transcriptional targets of FOXO1a.
We sought to identify molecules associated with PaC and PaC with diabetes (PaC-DM) using an integrative genomics approach, building from our previous methods in intersecting publicly-available gene expression measurements to find DNA variants associated with disease [ 11, 12].
To shed light into pathways that are activated by ribosomal stress in human cells expressing reduced levels of ribosomal proteins we have studied the transcriptome of three different cellular models of DBA looking for intersecting patterns of gene expression changes.
Awkward as this sounds in translation, the original German has the elegance that arises where accuracy of thought and economy of expression intersect.
We intersected the gene expression data with transcription factor binding data (based on ChIP-seq and DNase-seq) within 10 kb of the transcription start sites of expressed genes.
