Highway 5 also intersects Highway 8 near Kamsack.
Highway 5 then intersects Highway 57 at km 360.
It intersects Highway 600 and Highway 615, both of which have historical connections to Highway 71.
At km 64, it intersects Highway 2, where it begins a 6 km concurrency.
The freeway then intersects Highway 407 as it crosses into Brampton and passes beneath an electrical corridor.
It follows the old Cloverleaf Trail west through Devlin, where it intersects Highway 613, and Emo, where it merges with the Colonization Road.
The route intersects Highway 35 approximately 11 km east of Nesleton Station; both highways travel south concurrently for 1.5 km before Highway 7A branches east and Highway 35 continues south to Orono and Newcastle.
From Highway 57, the highway turns south and meanders to the southeast as it passes the access to the town of Coté (km 365) and through the towns of Runnymede (km 374) and Togo (km 387), where it also intersects Highway 357 and Highway 369.
While US 113 does not pass through Ocean City or the Delaware beaches, the U.S. Highway intersects several highways that serve the Atlantic Ocean resorts, including US 50, Maryland Route 90 (MD 90), US 9, and DE 1.
At km 21, Highway 5 intersects Highway 316.
