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Although we did not note any instances of treatment interruption, this might be due to the short follow up period: in a recent treatment interruption study done in South Africa the median time of interruption was 228 days [18].
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"Those kinetics are very different from what I've seen in treatment interruption studies, and we've done many," says Pablo Tebas, an infectious disease clinician at the University of Pennsylvania who heads the East Coast study of six participants.
The essentiality of the smpB gene has been deduced from systematic gene interruption studies performed in only three organisms Mycoplasma genitalium [26], Mycoplasma pulmonis [27] and Haemophilus influenzae [28].
They could potentially represent predictors of a functional cure or of the time to viral rebound after ART interruption, where treatment interruption studies are necessary to validate these predictors.
In light of observational cohorts such as VISCONTI (Saez-Cirion et al., 2013) where treatment cessation revealed individuals who remain aviraemic post TI, there is increasing interest in undertaking closely monitored treatment interruption studies in which ART would be re-started based on a detectable plasma VL.
Once the VL increased above 5000 RNA copies/ml, ART was reinitiated as Phase C. Treatment interruption (Phase B) followed by reinitiation of ART (Phase C), occurred a maximum of three times for each subject, prior to entry into Phase D. Phase D was a follow-up phase, a period of clinical monitoring following the completion of the mandated treatment interruptions study [21].
(Interruptions, studies have shown, prevent us from adapting to an experience, thereby heightening pleasure but also exacerbating pain).
Reported adherence was also comparable to previous non-interruption studies in children, which used similar questionnaires.
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