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As mentioned previously, discontinuation of therapy is the least favorable option because of poor outcomes associated with therapy interruption or termination.
It often manifests as a burning, stinging or prickling sensation, and usually peaks in the first minutes of treatment and declines significantly after 8 h. 2 It is usually intense and in some cases even intolerable for patients, sometimes requiring the interruption or termination of the process resulting in incomplete treatment.
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These processes require designated and long-term financial and technical resources to prevent untimely interruptions or termination.
Based on the results of these two safety evaluations, the DMSC will recommend continuation, interruption, amendment or termination of the trial.
In the management of depression, these deficits lead to frequent interruption or premature termination of drug therapy, which increases the risk of unfavourable depression outcomes [ 8, 9].
§ 225.113 Suspension or Termination of IRB Approval of Research.
§ 431.113 Suspension or Termination of IRB Approval of Research.
§ 1160.502 Proceedings after suspension or termination.
§ 987.82 Effective time, suspension, or termination.
§ 925.53 Modification, suspension, or termination of regulations.
§ 16.113 Suspension or Termination of IRB Approval of Research.
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