Thus, it is tempting to speculate that Aβ oligomers, acting through a yet unidentified mediator, caused the interruption of axonal transport, accumulation of vesicles and axonal dystrophy.
This may be explained by physiology: the fibrous tissue beneath the RPE may have decreased oxygen diffusion from the choriocapillaris, 13 resulting in interruption of active transport of exudative fluid across the RPE.
nAbts mechanisms are typically cell membrane disruption, and oxidation of cellular components caused by reactive oxygen species (ROS); interruption of transmembrane electron transport; and mitochondria and DNA damage caused by heavy metal ions and ROS.
A likely factor contributing to the interruption of intra-Golgi transport could be the fragmentation of the Golgi apparatus during mitosis (Fig. 3) 68– 71.
Another testable hypothesis implied by the model is a self-enhancing cycle of Cyt c release and ROS production by interruption of the electron transport.
8 9 Furthermore, surgical intervention in the lateral SPCA induced interruption of fast axonal transport and a segmental filling defect in the focal blood supply.
Desbois and Smith [ 197] summarized the antibacterial actions of FFA, ranging from membrane lysis and interruption of the electron transport chain to possible interferences with membrane proteins or nutrient uptake.
It is perceived that a class of anti-diabetic drugs, i.e., biguanides such as Metformin and Phenformin, exert their pharmacological activities via interruption of mitochondrial respiratory electron transport chain; likely via inhibition of Complex I [22], [23].
Finally, the analysis of the model suggests a direct experimental testing for the model-based hypothesis of a self-enhancing cycle of cytochrome C release and ROS production by interruption of the mitochondrial electron transport chain.
GAP-43 is upregulated after nerve injury, which is followed by regrowth of the injured nerve, and the upregulation is thought to be triggered by the interruption of the retrograde axonal transport [ 40, 41].
