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This transient inhibition of ERK1/2 phosphorylation might be caused relatively by Zras220 via interruption of the interaction between Raf-1 and MEK1/2 (Chen et al. [2001]).
Interruption of the interaction between CXCR2-CTD and LIM domain of LASP-1 by dominant negative and knock down approaches inhibited CXCR2-mediated chemotaxis.
It was reported that interruption of the interaction between HIV-1 CA and Cyclophilin A has opposite effects in human cells and non-permissive cells from other species [26], [27], [28].
This result suggests that interruption of the interaction between NKG2A and its ligand HLA-E might be an ideal therapeutic approach to treat CHB infection in humans.
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The EWS/FLI1 specifically binds the RHA fragment (AA 630 1020) and the interruption of this interaction induces apoptosis in vivo and in vitro in ESFT cells.
Therefore, specific interruption of the HDAC4-MAP1S interaction with short peptides or small molecules to enhance autophagy flux may relieve the toxicity of mHTT associated with Huntington's disease and improve symptoms of HD patients.
Since the enzymatic activity of ricin is based on its interaction with ribosomes, one can assume that interruption of this interaction will probably reduce its toxicity.
Interruption of the IN-SIP1 interaction through introducing the mutations in HIV-1 IN or with synthetic peptides corresponding to the binding motif of the IN for SIP1 resulted in abrogation of reverse transcription, indicating that IN-SIP1 interaction is a prerequisite for efficient HIV-1 infection.
As these authors propose, the effects of Nab-PTX on cancer stroma could be a consequence of the direct elimination of cancer cells and interruption of the cancer cell stroma interactions.
This demonstrates the interruption of the E-selectin:uMUC1 interaction as first described in previous work.
Some would go as far as to say that averting gaze benefits cognitive performance not only due to the disengagement of attention from a complex stimulus, but also because of the interruption of demanding social interaction processes involved in face-to-face communication (e.g. Markson & Paterson, 2009).
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