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In most cases, treatment of MOH includes an abrupt interruption of medication overuse through appropriate supportive care and the introduction of prophylactic treatment.
Suffering an adverse reaction to the drug (Yes/No), interruption of medication (Yes/No), and the reason for such interruption.
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In addition, interruption of medications which act on the central nervous system (CNS), including opioid analgesics, antidepressants and antipsychotic medications, confer a risk of adverse withdrawal events [ 9- 13].
In our planned analysis, we will further estimate the effect of the use and interruption of medications on withdrawal and relapse symptoms and illness outcomes.
The study objectives were to (A) assess the effects of interruptions on medication verification and administration errors, and (B) design and test the effectiveness of targeted interventions at reducing these errors.
Even though interruption of this medication did not result in clinical improvement, we cannot be certain that Dabrafenib alone could have caused the uveitis.
An interruption of study medication of no more than 14 consecutive days is permissible.
However, a perioperative interruption of antiplatelet medication is still frequently practiced for dental procedures [ 8].
Three rofecoxib-treated patients experienced AEs that led to temporary interruption of study medication (Table 4).
Throughout the study, 45% of patients required a dose reduction of neratinib and/or paclitaxel due to an adverse event and 72% of patients required a temporary interruption of study medication due to an adverse event.
Although the latest reports suggest continuation of clopidogrel intake in this regard [ 14– 17], perioperative interruption of antiplatelet medication is still frequently performed due to the fear of an increased risk of severe hemorrhage [ 18, 19].
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