Sentence examples for interruption of key from inspiring English sources

Insight into the molecular pathogenesis of GBM has led to the recent development of targeted therapeutic strategies aimed at the interruption of key molecular signaling pathways.

Mitochondrial energy supply is fundamental to cellular viability, and the interruption of key mitochondrial processes disrupts normal cellular bioenergetics, impairs cellular function, and subsequently leads to cell death by either necrosis or apoptosis [ 24].

By doing so, we will be better positioned to develop therapies based on interruption of the key signaling pathways that are responsible for the malignant phenotype.

Data obtained from these studies suggest that the function of the different immune regulatory pathways is not redundant in the pathogenesis of T cell exhaustion and combinational interruption of multiple key regulatory pathways might be required to reverse the dysfunctional adaptive immune response 29, 116.

Since rhodesiense HAT is a zoonosis, where the animal reservoir plays a key role, the interruption of the disease's transmission is not deemed feasible.

Thus, the midgut is the primary organ where interactions between the vector sand fly and the parasite occur and it represents a key target for interruption of Leishmania transmission.

This interruption of vascular support is thought to be a key mediator of multiple secondary injury cascades, all of which contribute to loss of functional tissue (Nelson et al., 1977).

128 On the other hand, since rhodesiense HAT is a zoonosis where the animal reservoir plays a key role, its elimination (the total interruption of disease transmission) is not regarded as feasible.

Glutamate synthase is a key enzyme in ammonia assimilation, and the interruption of HVO_0869 is expected to result in unbalanced glutamate and nitrogen metabolism.

Edmund, whose gentle demeanour disguises a strong mind, ignored the barrage of distractions that accompanied his return from a bathroom break to contest the fifth set and broke at the first time of asking, then held his nerve in the fading light against a backdrop of loud French interruptions at key moments.

These findings have shown that Payena dasyphylla might contained potential phenolic compounds that inhibiting the key enzyme in osteoarthritis development, which is the hyaluronidase enzyme through interruption of HYAL1 and HYAL1 gene expressions.