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We reasoned that if Drk was required for the effect of D-CblL over-expression, the interruption of interaction between Drk and D-CblL would block the D-CblL over-expression effects.
Interruption of interaction between these cell types or selective inhibition of their activation or survival represents a promising therapeutic strategy.
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We define decoupling here and the interruption of interactions between plants and soil via soil inputs and microbial community responses (Bardgett et al. 2013).
Since the enzymatic activity of ricin is based on its interaction with ribosomes, one can assume that interruption of this interaction will probably reduce its toxicity.
This transient inhibition of ERK1/2 phosphorylation might be caused relatively by Zras220 via interruption of the interaction between Raf-1 and MEK1/2 (Chen et al. [2001]).
Interruption of the interaction between CXCR2-CTD and LIM domain of LASP-1 by dominant negative and knock down approaches inhibited CXCR2-mediated chemotaxis.
It was reported that interruption of the interaction between HIV-1 CA and Cyclophilin A has opposite effects in human cells and non-permissive cells from other species [26], [27], [28].
The EWS/FLI1 specifically binds the RHA fragment (AA 630 1020) and the interruption of this interaction induces apoptosis in vivo and in vitro in ESFT cells.
This result suggests that interruption of the interaction between NKG2A and its ligand HLA-E might be an ideal therapeutic approach to treat CHB infection in humans.
Reduced AAAs after interruption of IgE interactions with inflammatory cells using either FcεR1-deficient mice or cells, or anti-IgE antibodies, may associate with reduced circulating cytokine levels.
For this purpose, we analyzed the changes in gene-expression profile (GEP) following interruption of cell niche interactions due to BM aspiration.
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