Similarly, increase stocks of medications in the health centers to anticipate interruptions of drug supply.
Conflict-affected countries often suffer severe disruptions to disease control programmes, interruptions of drugs and medical supplies, destruction of infrastructure, displacement of communities, and flight of health workers [ 2].
That requires strong drug supply systems with zero tolerance for an interruption of ART drug supply, strong and locally appropriate counselling to promote adherence, support for patients who don't have the resources to access care, re-engagement of patients who have stopped going to the clinics, alternative ways to deliver care such as community-based ART groups, and strong medical record systems.
One is an experimental study evaluating the impact of interruptions on drug entry errors [ 10].
Examples of non-ideal "real-world" situations include poor adherence, late entry into therapy, drug stockouts, unauthorized re-distribution of antiretrovirals, and interruption of multi-drug regimens in which one drug has a longer half-life, which creates an interval of "effective monotherapy" when only this drug is present at high levels [ 1].
Suspected adverse events leading to a planned interruption of trial drug occurred in 18 patients (12 co-trimoxazole, 6 placebo); all except six (all co-trimoxazole) resumed the trial drug.
Interruption of the drug after 60 days' treatment with celecoxib induced the reappearance of painful symptoms in two patients.
"No change" was defined as when empiric therapy was maintained without modification, "Escalation of therapy" was defined when there's a switch to or addition of an antibiotic with a broader spectrum, and "De-escalation" when there's a switch to or interruption of a drug class resulting in a less broad spectrum of coverage.
The primary end points were all cause mortality and adverse events leading to an interruption of trial drug.
