Sentence examples for interruption of dosing from inspiring English sources

Five patients experienced at least one hepatobiliary event that led to an interruption of dosing.

One infusion-related reaction (grade 1) was reported in the 5.0 mg/kg/week multiple-dose group and resolved after treatment with antihistamine and temporary interruption of dosing.

Overall, adverse events were reversible and manageable with interruption of dosing and dose reduction.

One subject in the 5.0 mg/kg/week multiple-dose group reported a grade 1 infusion-related reaction (pruritus and urticaria) that required temporary (48 minutes) interruption of dosing and was judged as probably related to MEDI-546.

To avoid this potential increase in docetaxel exposure, an investigation of temporary interruption of axitinib dosing around the time of docetaxel administration is warranted.

8 When treatment interruptions varied from 3 to 11 months, the mean time to relapse was found to be 3.1 months 4; this corresponds with the data on mean α4-integrin blockade dropping from 90%to30%0% by week 12 of dosing interruption and further to 10% at weeks 16 24.

Finally, in June 2011, the ESA label information was revised, the primary changes being removal of the Hb target range of 10 to 12 g/dL and inclusion of dosing and administration language focused on reduction or interruption of ESA dosing when Hb concentrations approached or exceeded 11 g/dL [ 7, 16].

Noting that the majority of patients had received at least one previous chemotherapy regimen, our data suggest that interruption of axitinib dosing before administration of chemotherapy may improve clinical outcomes compared with continuous dosing.

The study protocol required temporary interruption of eltrombopag dosing when a patient's platelet counts were > 400,000/μL.

A high number of paclitaxel infusion reactions was noted during the second administration (59%) and this prompted interruption of tosedostat dosing for 5 days around every second and subsequent paclitaxel infusion.

Dose-limiting toxicity was defined as drug-related nonhaematological toxicity ⩾grade 3 (excluding untreated nausea and vomiting), grade 4 granulocytopenia lasting >5 days, or associated with fever/infection, grade 4 thrombocytopenia, interruption of tipifarnib dosing for >4 days because of toxicity and grade ⩾2 neurotoxicity or ototoxicity, which did not improve to grade 1 or less within 3 weeks.