Exact(10)
However, VZV vaccination without interruption of chemotherapy would be preferable.
In addition, CVL-related acute morbidities lead to loss of CVL and interruption of chemotherapy [ 19- 31].
Although the interruption of chemotherapy and/or radiotherapy would have worsened prognosis, this cannot be confirmed during our study period.
Severe toxicity was defined by the onset of one of two major events: toxic death or interruption of chemotherapy due to toxicity.
The predictive value of MTX variables on severe toxicity was analysed considering toxic death (n=2) and interruption of chemotherapy due to toxicity (n=5) as events.
The reason for no subsequent measurements in the remaining 4 patients was interruption of chemotherapy in 3 cases and technical problems with sample collection in one case.
Similar(49)
No severe acute hematologic toxicity requiring interruption of the chemotherapy administration was recorded.
Thus, the EBV-positive tumoral status of elderly DLBCL patients who undergo R-CHOP chemotherapy may not predict their survival but their EBV status may contribute to the early interruption of R-CHOP chemotherapy.
The EBV-positive DLBCL patients with early interruption of R-CHOP chemotherapy showed a trend toward a high EBV DNA titer (≥1000 copies/mL; P = 0.091).
Data were collected from the starting date of chemotherapy until interruption, for up to seven drugs in each cycle of chemotherapy (corresponding to a theoretic 21-days period), with the daily dose and the number of days of assumption recorded.
Severe asthenia was followed by interruption of both radiotherapy and chemotherapy till recovery.
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