Treatment-emergent AEs of grade 3/4 ALT or AST elevations were reported in three (9%) and three (9%) patients, respectively; these events were managed by dose interruption in two and two patients, respectively, and all resolved with no patient discontinuing treatment.
Most patients had transient central nervous system (CNS) side effects, necessitating dose reductions or temporary treatment interruption in eight and cessation of therapy in two patients.
Diarrhoea led to dose reduction or interruption in four patients at dose levels of 900 mg BID or higher, in one of them to permanent discontinuation.
This was done to account for multiple testing biases given the large number of events that were investigated as interruptions in four separate suicide time series.
Thus, the M184V resistance mutations decreased quickly after treatment interruption in all five patients.
Despite the potential for disruption, the program did not suffer from interruption in the three years since ART commenced.
What is now called the Sacred Cod has hung for three centuriesthough with interruptions, and in three successive incarnationsin the chamber of the Massachusetts House of Representatives (or its predecessor, the House of Assembly of the Province of Massachusetts Bay).
We investigated the two stages of object file formation (individuation and identification/consolidation) using the two forms of contour masking (integration and interruption) in a fully counterbalanced two-by-two design.
With most email applications set to check for new mail every five minutes, that can add up to 96 interruptions in an eight-hour day.
During the interruption in HMIPv6, only three packets are forwarded by the HA with a transmission delay of 1413 ms. In Tables 2 and 3, the average TCP throughput, average packet transmission delay, and average handoff latency are calculated for MIPv6, HMIPv6, CNLP, and ADA.
