Adverse events were the most common reason for dose reductions, dose interruptions, and cycle delays.
One possible explanation is that the higher incidence of some adverse events in the sunitinib arm required more dose reductions, dose interruptions, and cycle delays, leading to a shorter overall median duration of treatment in the sunitinib arm.
Interestingly, the prediction of FA biosynthesis up-regulation, TCA cycle interruption, and glycolysis interruption agreed with San and Li (2013), strengthening the robustness of the integrated approach of computational strain design and flux analysis tools.
"If you put a construction manager between the contractor and the homeowners, you sometimes get an interruption of that cycle of communication".
For Ford, always so sensitive to the changing of seasons and, as John Wayne puts it in "The Searchers," the "turning of the earth," this interruption of the cycle of nature carries an apocalyptic force, a foreshadowing of the war that would arrive within six weeks of the film's New York premiere.
Interruption of the cycle of pain and reflex muscle spasm are the most causes to relieve the symptoms; however, these effects have a short duration.
It seems, therefore, that a crucial step in Brucella pathogenesis is to sneak to its replicating niche without cell activation or cell cycle interruption.
By decreasing the supply of pyrimidines, leflunomide leads to interruption of cell cycle and decreased proliferation of activated lymphocytes and therefore is an interesting potential therapeutic agent in the treatment of HIV-1 infection.
Interruption of transmission cycle in the mosquito by key toxic molecules namely nitrates and nitrites that are required for successful killing of the parasite in the vector would require detailed knowledge of the complex interplay between Plasmodium and its mosquito vector.
Therefore, a decrease of the above mentioned metabolites, especially citrate, can further aggravate ketosis due to interruption of TCA cycle and lack of amino acids.
