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Dose interruption criteria within treatment cycle.
Additional interruption criteria were a lack of social interaction, refusal to eat, and shaggy fur.
Accordingly, the interruption criteria were not fulfilled during conventional or noisy PSV.
Specific dose modification and treatment interruption criteria for sorafenib and erlotinib were applied.
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Exclusion criteria were interruption of blood donation and onset of symptomatic hypotension.
In case the body weight dropped by 10% or more, the experiment was interrupted until the monkey regained the lost weight (this criterion for interruption was not met during the course of the present experiments).
Inclusion and exclusion criteria for sedation interruption were based on the protocol, as used in two previous randomized controlled trials [ 13, 24].
To date, 5 of 12 formerly S. japonicum endemic provinces and >60% of disease-endemic counties have reached the national criteria of transmission interruption, and the number of human infections has been reduced by >90% (6 – 8 ).
Three patients (0.2%) continued triple therapy despite having met the week 4 virological criteria for anticipated TVR interruption.
The neutropenia occurred on day 8 of the combination therapy, and the patient was withdrawn from this study according to a discontinuation criterion (i.e., interruption of investigational drugs lasting >14 days).
Bone erosion was defined as a discrete interruption of the cortical surface, based on standard plain film radiograph criteria [ 19, 20].
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