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The two patients in our study were treated with the interrupted approach to avoid possible augmentation of adverse events.
Other observational studies with a more interrupted approach showed equivalent bleeding and embolic events compared to therapeutic warfarin [ 84– 84].
Our cases suggest that the interrupted approach was both well tolerated and effective, and that sorafenib combined with TACE is a good strategy for clinical practice.
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The timing of the HiP grant is well-defined and fixed, therefore using the interrupted time-series approach any effects within that window can be observed.
We applied the same interrupted time-series approach for the control departments and compared the post-intervention trend changes (β2) in the medical service with the average effect (β2) in the control departments.
This will include using interrupted time series approaches with the longitudinal routine data, to detect abrupt changes in the time course of process indicators, and relate them to changes in inputs.
We chose a difference-in-differences analytic framework because the study period was relatively short, and we did not have adequate data to control for temporal trends using a more refined approach like interrupted time series.
The major strength of this study was the interrupted time series analysis approach that capitalized on naturally occurring geographic and time controls owing to the broad but variable implementation of OEND in Massachusetts.
For use of services, we will use an interrupted time series evaluation approach, 50 where monthly measures (12 measures each year) over the year preceding the start-up and during the carrying out of the study will first allow us to perceive trends and their stability over time.
The approach of interrupted time-series analysis has advantages over a simple before/after comparison because it controls for long-term trends and seasonality in the data, but it may be influenced by other events occurring at about the same time as the event of interest (historical bias) [ 20, 21].
Owing to our scepticism about the validity of the published effect estimates of the intervention programme and our general interest in having more robust evaluations of large-scale interventions, we sought to conduct a new analysis with a more rigorous methodological approach, that is, an interrupted time-series analysis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com