A detachment of any design interrupts the loop and flow of evidence so that the network estimates correspond, if existing, to their direct estimates and the inconsistency of the network is dissolved.
Straightforward pharmacological intervention with well-known GABA antagonists could be used to counteract the misregulation and to interrupt the pathological feedback loop.
Maintaining appropriate autophagic flux therefore could help conserving a sufficient amount of rescued F508del-CFTR at the PM to interrupt the feed forward loop that ignites CFTR disposal.
Accordingly, SMART adopts an event-based asynchronous pattern to handle high frequency data packet arrival and process the data on a separate thread in the background without interrupting the main loop.
Remarkably, the Geminivirus replicase, Rep/AC1/C1 and the embedded protein AC4/C4, downregulate the expression of host DNA methyltransferases MET1 and CMT3 (Pumplin and Voinnet, 2013; Rodriguez-Negrete et al., 2013); hence, it interrupts the reinforcing loop of histone and DNA methylation.
Note that if decolonization therapy in patients would not eradicate MRSA carriage, but only suppresses infectiousness by lowering the bacterial load, decolonization is conceptually similar to patient isolation as both reduce infectiousness without interrupting the feedback loop of colonized patients being readmitted.
A strategy for the reactivation of the pro-apoptotic p53 activities in such tumours is therefore to interrupt the p53 HDM2 feed-back loop, either by blocking the protein protein interaction between the p53 N-terminal domain and HDM2, or by inhibiting the E3 ligase activity of HDM2.
A Norwegian group from Oslo went a step further and hypothesized that administration of tocilizumab in patients with non-ST elevation myocardial infarction may interrupt the self-perpetuating inflammatory loops of cardiovascular damage resulting in improved plaque stability with potential secondary beneficial effects on myocardial damage.
This spiral tube assembly has greater column capacity than the original tubing because of an increase in radial grooves from 4 to 12 to accommodate more spiral layers and 12 narrow spots instead of 4 in each circular loop to interrupt the laminar flow that causes sample band broadening.
These analyses showed that mRNA-Hsp65 did not have significant loops or arms that could interrupt the translation process.
