Rapidly developing technologies such as chip array-based genotyping platforms have facilitated recent large-scale interrogation of the human genome.
We previously identified this gene through bioinformatics interrogation of the human EST database (NCBI accession number AF254415).
Most interestingly, reciprocal interrogation of the human genome using the LRRCE motif from the zebrafish ECMX sequence gave a hit in chromosome X (accession code XP_001714654, currently known as hypothetical protein LOC389904), upstream of the human biglycan gene (Xq28).
Research on the etiology of post-traumatic stress disorder (PTSD) has rapidly matured, moving from candidate gene studies to interrogation of the entire human genome in genome-wide association studies (GWAS).
These alterations may constitute an important subject of interrogation from the human point of view (for children conceived by ART).
Interrogation of the global FANTOM5 human promoter expression atlas (N = 988 libraries) showed that the repertoire of OR identified in the SN has a complex pattern of expression (Additional file 10: Figure S8).
Another strategy would be to incorporate hPSC-derived cells into chimeric animal models, e.g. replacing a mouse's endogenous hepatocytes with engrafted hPSC-derived hepatocytes (Yusa et al., 2011), thus allowing for interrogation of the effects of human genetic variation in whole-animal models.
7– 9 The development of sets of FISH probes for the simultaneous interrogation of all the unique human subtelomeres 29, 31, 32 has allowed for the detection of submicroscopic chromosomal abnormalities in patients with idiopathic mental retardation but without features suggestive of a particular syndrome.
Ultimately, metabolic reconstructions provide a framework for the interrogation of human pathogens and serve as a platform for generation of future experimental hypotheses.
