Sentence examples for interrogating the mechanisms from inspiring English sources

Our work suggests that the interplay among sleep, stress, and neuropathology emerges from genetic influences on gene expression and their collective organization through complex molecular networks, providing a framework for interrogating the mechanisms underlying sleep, stress susceptibility, and related neuropsychiatric disorders.

In this regard, research specifically focused on interrogating the mechanisms and ability of tumour cells to circumvent and bypass apoptotic death mechanisms through adopting viable cellular fates such as cellular senescence and cytoprotective autophagy is warranted.

Although molecular biology and genetic technologies have been the primary drivers of this transformation, synthetic strategies have been increasingly utilized to interrogate the mechanisms of embryonic patterning with spatial and temporal precision.

The described approach expands the search for disease related genetic changes, indicates the time of their occurrence and begins to interrogate the mechanisms involved.

Our data would suggest that ADAMTS-12 acts in a cell automomous manner regulating ECM activity independent of its endogenous proteolytic function, however more studies are required to fully interrogate the mechanisms by which ADAMTS-12 regulates αv integrin transcription and function.

We further interrogated the mechanisms by which Taspase1 sustains cyclins levels.

The midface thus offers a unique opportunity to interrogate the mechanisms of signal specificity between these two RTKs in a developmentally relevant system.

These results provide a comprehensive stem cell proteomic resource and enable new approaches to interrogate the mechanisms that regulate cell fate specification.

Here we make use of changes in Bd virulence that occurred in a laboratory setting to interrogate the mechanisms of variation in pathogen virulence.

This co-culture system demonstrates tumor-dependent subversion of stabilizing mural cell-endothelial cell interactions and provides a means to interrogate the mechanisms by which tumors disrupt inhibitory signals required for this effect.

Thus, our proteomic data set will provide an important resource of cell-surface proteins that are present on stem cells and could be used in future functional studies to interrogate the mechanisms of self-renewal and differentiation.