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Our Nrp1 VEGF− line provides a powerful new genetic tool for selectively interrogating the function of VEGF-NRP1 binding in broad areas of basic research and translational study.
The Noto- cre mouse described here will be a valuable tool for interrogating the function of molecules that regulate the function of notochordal cells within the IVD, with the eventual goal of identifying candidate biological treatments for disc degeneration.
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TALENs thus constitute a powerful tool to interrogate the function of DNA sequences within complex genomes.
In a complimentary approach, two additional groups utilized genetically altered mice that harbored embryonic deletion of Yap in the heart to interrogate the function of endogenous Yap during heart development [61],[115].
In the present article we describe the design and implementation of selective zinc chelators as antagonists to interrogate the function of mobile zinc, with an emphasis on the pools of vesicular zinc in the terminals of hippocampal mossy fiber buttons.
Because homologues of the animal apoptosis system do not appear to exist in the budding yeast S. cerevisiae, this organism provides an attractive system in which to interrogate the function of apoptosis proteins without interference from other family members.
Furthermore, while enrichment analysis, such as in Gene Ontology categories, is an efficient way to interrogate the function of a given gene set of interest, interactome-based enrichment investigation offers a particularly powerful perspective on functional relations between the individual genes that were found to be differentially expressed.
We are greatly limited by the breadth and specificity of available assays to interrogate the function of a DNA fragment.
Next, siRNA was used to interrogate the function of CREB1 in HO-1 induction downstream of PKCε.
To learn more about these nine miRNAs, we interrogated the function of their homolog in C. elegans.
In addition, we further interrogated the function of a particular epigenetic regulator in mouse and human pre-implantation development.
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