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To identify cancer driver genes in this region, we interrogated the function of each of these genes by loss- and gain-of-function genetic screens.
In addition, we further interrogated the function of a particular epigenetic regulator in mouse and human pre-implantation development.
To learn more about these nine miRNAs, we interrogated the function of their homolog in C. elegans.
We interrogated the function of disrupted meiotic cDNA1 (DMC1), a homolog of RAD51, the primary recombinase used in mitotic cells to search and recombine with the homologous DNA template.
Based on the elevated cellular density in GBM, which increases the opportunity for direct cell communication, and the dependence of CSC maintenance on cell-cell interactions, we interrogated the function of connexins in GBM.
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We further interrogated the functions of ALDH2, CCNE1 and SMAD3 by searching genes that are functionally similar, or have shared properties using GeneMANIA [ 23].
We next interrogated the functions of genes that were share, or specific in one of the two cancers.
Trinh, L. A. et al. A versatile gene trap to visualize and interrogate the function of the vertebrate proteome.
TALENs thus constitute a powerful tool to interrogate the function of DNA sequences within complex genomes.
To interrogate the function of mRNAs that are both maternally and zygotically expressed, it is common to examine the embryonic phenotypes derived from female germline mosaics.
To interrogate the function of EphA2 SAM domain, we generated three serially truncated mutants that were tagged with enhanced green fluorescence protein (eGFP) in a retroviral expression vector (Fig. 1A).
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