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In addition, we further interrogated the function of a particular epigenetic regulator in mouse and human pre-implantation development.
To learn more about these nine miRNAs, we interrogated the function of their homolog in C. elegans.
We interrogated the function of disrupted meiotic cDNA1 (DMC1), a homolog of RAD51, the primary recombinase used in mitotic cells to search and recombine with the homologous DNA template.
Based on the elevated cellular density in GBM, which increases the opportunity for direct cell communication, and the dependence of CSC maintenance on cell-cell interactions, we interrogated the function of connexins in GBM.
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We further interrogated the functions of ALDH2, CCNE1 and SMAD3 by searching genes that are functionally similar, or have shared properties using GeneMANIA [ 23].
We next interrogated the functions of genes that were share, or specific in one of the two cancers.
TALENs thus constitute a powerful tool to interrogate the function of DNA sequences within complex genomes.
LvIA may therefore be a highly valuable probe to interrogate the function and significance of α3β2 nAChRs in normal and disease physiology.
In a complimentary approach, two additional groups utilized genetically altered mice that harbored embryonic deletion of Yap in the heart to interrogate the function of endogenous Yap during heart development [61],[115].
In the present article we describe the design and implementation of selective zinc chelators as antagonists to interrogate the function of mobile zinc, with an emphasis on the pools of vesicular zinc in the terminals of hippocampal mossy fiber buttons.
Because homologues of the animal apoptosis system do not appear to exist in the budding yeast S. cerevisiae, this organism provides an attractive system in which to interrogate the function of apoptosis proteins without interference from other family members.
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