Sentence examples for interrogate the function of from inspiring English sources

TALENs thus constitute a powerful tool to interrogate the function of DNA sequences within complex genomes.

In a complimentary approach, two additional groups utilized genetically altered mice that harbored embryonic deletion of Yap in the heart to interrogate the function of endogenous Yap during heart development [61],[115].

Because homologues of the animal apoptosis system do not appear to exist in the budding yeast S. cerevisiae, this organism provides an attractive system in which to interrogate the function of apoptosis proteins without interference from other family members.

In the present article we describe the design and implementation of selective zinc chelators as antagonists to interrogate the function of mobile zinc, with an emphasis on the pools of vesicular zinc in the terminals of hippocampal mossy fiber buttons.

Furthermore, while enrichment analysis, such as in Gene Ontology categories, is an efficient way to interrogate the function of a given gene set of interest, interactome-based enrichment investigation offers a particularly powerful perspective on functional relations between the individual genes that were found to be differentially expressed.

Next, siRNA was used to interrogate the function of CREB1 in HO-1 induction downstream of PKCε.

Thus, the thymocyte differentiation assay allows us to interrogate the functions of mir-181a-1 mir-181a-1 mir-181a-1siologicandy relevant mRNA and miRNA milinu.

The Dobbelstein lab therefore performed a comprehensive siRNA screen to interrogate the functions of known ubiquitin ligases and deubiquitinating enzymes in the DNA damage response to cisplatin treatment.

One of the next exciting challenges to our understanding of how complex behaviors are specified at a molecular-genetic level will be to develop tools to interrogate the functions of specific transcript isoforms in a cell-specific manner.

To generate tools to specifically interrogate the functions of GPN2 and GPN3 we created mutant alleles of each gene using a mutagenic PCR approach described previously (Ben-Aroya et al. 2008).

To more definitively interrogate the functions of PP4 in vivo, we generated mice carrying a floxed ppp4c allele (PP4f) by embryonic stem cell targeting, and introduced proximal Lck promoter-driven Cre recombinase transgene (Lckcre) to mediate T cell-specific deletion of ppp4c (Lckcre:PP4f/f).