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To explore the mechanism(s) by which androgen-dependent PCa cells become resistant to hormonal therapy, we used microarray technology to interrogate the differences in gene expression between androgen-responsive and therapy-resistant cell lines.
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Susceptibility contrast-enhanced MRI using the USPIO contrast agent feruglose was used to interrogate any differences in magnitude and distribution of fractional blood volume between size-matched C6 and AS7 tumours.
In addition, to control for the differences in detection efficiency between spots, each probeset (the collection of probes designed to interrogate a given gene sequence) was normalized to its median across all chips or arrays.
Future studies could interrogate possible task differences in the extent to which FP and other attentional control networks are engaged either bilaterally or relatively unilaterally, and what such differences may mean in terms of information processing.
We take advantage of rich longitudinal data from a racially and ethnically diverse population followed over a period of increased risk for weight gain, but the small number of individuals with diabetes precluded our ability to fully interrogate differences in Hispanics and Asians in multivariable analyses.
We used three methods of statistical analysis to interrogate similarities and differences in whole-brain activity across retrieval tasks, while focussing on prefrontal cortex (PFC) activations: multivariate partial least squares analysis (PLS), univariate statistical parametric mapping (SPM) and conjunction analysis.
"The work interrogates the condition of difference in both art and world contexts: does Axel meet resistance because of his incongruous visual identity, or his transgressive means of investigation?" asks Barrois, whose project is updated on a dedicated Instagram page.
We interrogated whether differences in KI67 levels reflect differences in stem cell potential.
In this study, we systematically interrogated global differences in gene expression between nectaries and non-nectary reference tissues, as well as between nectary types and developmental stages.
We further interrogated whether differences in excitatory and inhibitory synapses described above could underlie changes in synaptic strength, such as LTP responses, considered the cellular substrate of memory function [ 53].
Let's interrogate the role of race in these situations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com