This paper interrogates the planning, development, debate and abandonment of a massive infrastructure project in a remote area of northwest British Columbia.
Despite temporal differences in the ontogeny of the small intestine between human and mouse, the overall process of development is identical, making the mouse an accessible model to interrogate the process of human intestinal maturation.
In a complimentary approach, two additional groups utilized genetically altered mice that harbored embryonic deletion of Yap in the heart to interrogate the function of endogenous Yap during heart development [61],[115].
In future similar evaluations, it may be prudent to augment the 'rigour of development' domain to clearly interrogate the source of the guidelines document, including whether it is based on another reference guideline.
An emerging example is the development of surface-capture probes to interrogate the surface-reactive subproteome, a critical response gateway for active substances, as recently demonstrated for hepatocytes.
Using this RNAi-compatible OP50 strain and the other bacterial strain HT115, we feed worms different diets while delivering RNAi to interrogate the genetic basis underlying diet-dependent differential modulation of development, metabolism, behavior, and aging.
Most importantly, the availability of this information has led to a technological boom, with the development of high-throughput methods that could be used to interrogate the wealth of data available in the human genome and transcriptome.
Given the rapid development of next-generation sequencing, it is now feasible to directly interrogate the PCR products from the 4C technology (hereafter referred to as "4C-Seq").
With the development of more sensitive fluorescent and bioluminescent reporters and sophisticated imaging equipment, it has become possible to interrogate the spatiotemporal architecture of the circadian cycles of gene expression in the SCN.
The inaugural conference had the following objectives: To gather interested local and international scholars to interrogate the theoretical, conceptual, methodological and empirical as well as policy issues pertaining to south south relations and development.
