We used a common-path Fourier domain optical coherence tomography to interrogate the change of FP cavity length through phase-sensitive detection.
In our FPI-FS, the length of FP cavity changed with force and we used a common-path Fourier domain optical coherence tomography (CP-FD-OCT) to interrogate the change of cavity length by phase-sensitive detection.
In this study, we systematically interrogated the changes in chromatin structure of human subtelomeres upon cellular senescence.
Like evaluating neutrality using 1-mutant neighbors, 2D SHAPE interrogates the changes in RNA structure when making single mutations to an RNA sequence.
Compared with classical genetic screens, such as transposon-mediated mutagenesis and somatic clonal analysis [ 5- 7], RNAi technology is revolutionary in that it allows investigators to quickly interrogate the phenotype changes that occur upon knocking down individual genes at the genome scale [ 8].
SPR biosensors interrogate the resonance angle changes to detect and quantify bioagents.
We used single-cell gene expression profiling of GMPs, either wild-type or transduced with a control vector or a Ddit3-expressing lentivirus, to interrogate the transcriptional program changes imposed by enforced expression of Ddit3 and to inspect its role in remodeling of the transcriptional networks underlying lineage progression and/or identity.
Mouse models overcome some key hurdles for biomarker discovery, including technology development [16]; more precise matching of cases and controls to reduce genetic, age, and environmental variables; interrogating the dynamic changes in the plasma proteome through disease progression; and integrating results with the extensive biological knowledge bases [17].
To further interrogate the functional relevance of excitability changes accompanying vestibular activation, we assessed changes in 1) phosphene percepts—specifically phosphene size and intensity and 2) response entropy derived from an information theoretic analysis (see also Supplementary Materials).
The array platform used to interrogate the C2C12 response to transfection measures genome-wide transcriptional changes using 18,129 probes.
