Sentence examples for interrogate sequence from inspiring English sources

Compared to markers based on size discrimination or hybridization, SNPs directly interrogate sequence variation and can reduce genotyping errors [ 12].

Another useful resource for investigating candidate SNPs is the ECCO database (Nguyen et al. 2014), which enables researchers to interrogate sequence variation of functional elements for each of 19 tissues/cell types.

Because the SC and TL proximal breakpoint regions appear to be coincident on the cytological map (Dobzhansky 1944), only one primer pair was designed to interrogate sequence evolution at both inversion breakpoints.

Other methods such as in situ hybridization can effectively interrogate sequences in single cells in addition to providing the physical address of transcripts or DNA in intact tissue.

In addition, many arrays are purposefully biased to interrogate sequences originating from 3' ends of mRNA encoded by the 3' terminal exon of previously annotated genes.

In the analysis of these new expression data, we included only those probes that interrogate sequences that are identical in XL and in XB based on 454 pyrosequencing of XB cDNA.

Spectra were then used to interrogate sequences in the Swiss-Prot database using Mascot Daemon software v 2.2.2 (Matrix Science, Boston, MA) running the Mascot server (V 2.2).

One of the sophisticated methods is to estimate nonsynonymous and synonymous substitution rates for interrogating sequence dynamics and constructing phylogenetic trees.

As expected, no meaningful variation in signal strength is detectable in this case, ruling out that simply the number of probes, irrespective of probe vs. interrogating sequence homology, is influential.

Inspired by previous sequence-based computational prediction algorithms [Ng and Henikoff, 2001; Thomas et al., 2003], our unweighted/species-independent method interrogates sequence conservation through the underlying amino acid probabilities modeled by the internal match states of several HMMs representing the alignment of homologous sequences and conserved protein domains.

We measured DNA methylation in ejaculated spermatozoa, interrogating sequences in repetitive elements, promoter CpG islands, and differentially methylated regions (DMRs) of imprinted genes.