From those, 217 genes (from all 19,389 genes tested in the meta-analysis, see supplementary material Table S1) were interrogated finding 26 candidates in the meta-analysis (P-value = 9.9587e−13).
These components of the framework highlight a number of guiding themes which are then used to interrogate the findings and orient the analysis and understanding of the results.
It will be interesting to interrogate these findings further to see how changes in the Keratin-15-GFP population identified in this study might affect the functional behavior, fate and cellular hierarchy in other skin stem cell populations and their derivatives.
We further interrogated emergent findings from interview and documentary data by searching for negative cases, drawing mind maps and 'brainstorming' (see Riley 2000 for an explanation of brainstorming qualitative data [ 37]).
In the present study, we have used an extended DotScan™ microarray [ 25] to detect surface antigen profiles of live melanoma cells and leukocytes from fresh surgically excised metastatic melanoma LN tumors (AJCC stage IIIb/c disease) and interrogated the findings with prospectively collected clinical and follow up data from each patient.
Thus, manual examination is necessary to interrogate the atypical findings.
SAL and JN then adapted procedures described by Pound et al [ 49] for synthesising, exploring, further mapping, integrating propositions, interrogating and understanding findings from all phases, and incorporating our expert knowledge.
"His interrogator interrogated.
Two researchers independently extracted findings by interrogating each study using the following questions developed from the aims of the review: 1.
To extend these findings we interrogated the publically available database of 212 lung squamous cell carcinomas in the TCGA to determine the incidence of alterations that are predicted to compromise ATM and ATR kinase activation and the FA pathway of ICL repair.
