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The promoters with transgenerational differential methylation were analyzed in the online algorithm Repeat Masker in order to interrogate changes in the representation of particular repetitive elements.
The 500 kHz RF was superimposed on top of low-frequency TEVC (<30 kHz) allowing the RF to continuously interrogate changes in charge displacement mobility during whole-cell depolarization.
To interrogate changes in structure that give rise to the observed dynamical differences, we measured the chemical shift differences between monomeric Aβ43 and Aβ42.
We have constructed an S. ratti cDNA microarray and used it to interrogate changes in gene expression during the free-living phase of the S. ratti life-cycle.
High-dimensional flow cytometry, and more recently mass cytometry, have been exploited to interrogate changes in the cellular compositions before and after vaccination [ 10].
Finally, using prior knowledge of cognitive dysfunction in this group (O'Muircheartaigh et al., 2011 a ), we interrogate changes in thalamo cortical functional integration from this region of interest to the rest of the brain.
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Specifically, we interrogated changes in gene expression patterns in MEC cells caused by the knockdown of CRTC1-MAML2 fusion expression.
Using DNA microarrays, we interrogated changes occurring in GSCs following CBD treatment.
Genome-wide technologies are commonly used to interrogate transcriptional changes in discovery-based approaches.
To understand the signal transduction changes that accompany the cell-death-inducing perturbation of glucose addiction, Graham et al (2012) used a mass spectrometry-based approach to interrogate the changes in the phosphotyrosine proteome that follow glucose deprivation.
This is the first time that, to our knowledge, this technique has been used to interrogate transcriptional changes in cartilage ageing and, importantly, validation studies using RT-PCR demonstrated high correlation between methodologies and demonstrated reproducibility using a different donor set.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com