Such differences in untreated outcome need to be considered when interpreting trial results using outcome measures that were largely designed for studies of patients with AD.
Should RIAT authors contact original investigators for help in interpreting trial documents?
The near impossibility of accurate VAP diagnosis compels us to exert great caution when interpreting trial data and hospital surveillance data showing decreases in VAP rates.
The findings here from nearly 30 000 patient-years of data have implications for current clinical practice, for interpreting trial results and for designing future ones.
Although these guidelines implicitly recognise the importance of adherence in interpreting trial results, there are no recommendations for how to report adherence.
In summary, this trial provides a novel longitudinal evaluation of physical rehabilitation delivered across the continuum of patient recovery, highlighting the importance of understanding 'usual care' in interpreting trial results.
Adherence coverage is arguably the most relevant measure for interpreting trial results, as it provides an indication of whether sufficient study medication was taken to expect a biological response.
