Subsequently Meyre et al. identified further FTO heterozygous, loss-of-function mutations in obese as well as lean subjects, further clouding FTO's causative role [41] and illustrating the complexity of interpreting the function of this dioxygenase in energy balance [42].
Even when additional biological information is included, biclustering methods have to face the challenge of interpreting the function of each groups of genes.
Interpreting the function of this machinery is complicated, however, since most of the protein components have dual roles in translation and in translation-dependent RNA quality control pathways.
As one analytical technology for systems biology, metabonomics has displayed great power in screening metabolic biomarkers, describing metabolic pathways, and interpreting the function of complex biological systems [ 10].
This analysis also underscores the importance of epigenomic data, which became available only recently by ENCODE project (Table 1), in interpreting the function of the non-coding portion of the genome.
BlastX results against NCBI database and Blast2GO results were used to interpret the functions of the assembled 34,136 contigs, which were then used as the reference contigs for RNA-Seq analysis.
To deeper interpret the function of collected data, a series of functional analyses were performed, which included enrichment analysis, mutation annotation, gene disease network construction and mutation spectrum.
T lymphocytes play a key role in cell-mediated immune response, and the activation investigation of T lymphocytes in vitro can help researchers interpret the function of the whole immune system.
The experience of pain may be an opportunity to teach viscerally hypersensitive children to interpret the function of a variety of bodily signals (including those of hunger, emotions) thereby reducing fear of bodily sensations and facilitating emotion awareness and self-regulation.
