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Although we believe the results obtained from such samples are reliable, extra attention should be paid in interpreting the expression pattern of single genes, especially those identified from the placebo groups.
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This approach reduces the dimensionality of the problem; instead of interpreting the expression patterns of thousands of genes, discrete groups of genes can be categorized in a variety of ways.
For example, a single isoform may arise from multiple ASEs, which makes interpretation of the expression pattern of such a transcript very difficult to interpret.
While acknowledging the genetic evidence for precocious X inactivation [ 3, 7], the authors interpret the observed expression pattern to be inconsistent with the predictions of MSCI.
CAG and IAH generated and interpreted some of the expression patterns.
The published relapse-free-survival (RFS) times for patients in this trial are used to label each patient as <5 yrs RFS (blue) or >5 yrs RFS (red), allowing the physician to interpret the gene expression patterns in context with the end point of interest.
The expression pattern of HO-1 resembled the pattern of CSE expression.
AN carried out and interpreted the expression analysis.
The expression patterns can be interpreted along two lines.
In such cases, one species' trans environment may be unable to interpret the other species' enhancer, even if the expression patterns controlled by the orthologous enhancers are identical between the two species.
2) To interpret the effects of changing gene dosage as affecting cis versus trans effects, one also has to be mindful of the expression patterns of all of these genes relative to where Notch activation is occurring.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com