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Previous studies (reviewed in the Introduction section) have shown that attentional and interpretative biases can be modified successfully using these procedures.
This assessment will be repeated 2 and 12 weeks after the start of the intervention, so that change in attentional and interpretative biases can be ascertained (secondary outcomes).
Cognitive bias modification (CBM) targets attentional and interpretative biases associated with anxiety, dysphoria and depression and may be useful to treat depression in AD (DAD).
Before the intervention starts, all participants will complete a baseline assessment of attentional and interpretative biases, using assessment variants of the procedures described for the intervention.
We will use multilevel mixed models to analyse changes in CSDD, QoL and attentional and interpretative biases from baseline to weeks 2 and 12.
Although diagenetic alterations of ancient tissues often generate interpretative biases, CT scans have allowed differentiation between tissue structures and embalming materials.
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Of note, if Gapdh were chosen as reference for highly/lowly glucose sensitive beta cells, much of their observed differences would remain unnoticed, illustrating the inevitable introduction of interpretative bias by normalizing.
Attentional and interpretative bias data will be collected automatically by the study computer during the assessment.
Finally, while the recognition task we used to measure interpretative bias has well established validity, its reliability has yet to be formally examined.
Negative interpretative bias will be indexed by degree of relative speeding to identify target words in the latter condition compared to the former.
Third, the fact that we administered the attentional and interpretative bias tests in a fixed order means that we cannot rule out order confounds in the data.
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