Fig. 6 Geometric interpretation of diffusion matrix.
But there were both fibers and beads, thus making the interpretation of diffusion data very difficult.
The interpretation of diffusion parameters of white matter rests on what is known to drive diffusion anisotropy, namely axonal membranes, density and coherence, as well as myelin sheaths.
This paper also outlines the type of information which would enhance an understanding and interpretation of diffusion measurements on site-specific media.
Arrhenius interpretation of diffusion coefficients measured at 15, 25, 35, and 45 °C allowed calculation of the activation energies of diffusion for PEF and PET, which were similar at 47.1 ± 2.8 kJ/mol and 46.4 ± 3.0 kJ/mol, respectively.
Here we expand their work and present the numerical interpretation of diffusion and permeation experiments by solving the inverse transport problem which is formulated as the minimization of a weighted least squares criterion measuring the differences between computed and measured concentration values.
Another caveat that restricts the interpretation of diffusion indices is the discrepancy of anatomical findings among DTI investigations.
Tumor fibrosis may confound interpretation of diffusion findings as a low grade, fibrotic tumor may restrict diffusion to a greater degree than a higher grade, less fibrotic tumor.
The interpretation of diffusion tensor imaging (DTI) eigenvectors, known as multiple indices, may provide new insights into the main pathological models supporting primary or secondary patterns of WM disruption in AD, the retrogenesis, and Wallerian degeneration models, respectively.
It is worth noting the many important contributions of Patlak to the quantitative interpretation of diffusion in the brain; a study of Ca2+ diffusion in normal and thick slices [ 31] probably represents the most sophisticated analysis of radiotracers to date and may be compared with the later study using the RTP method by Hrabětová et al. [ 26].
This choice is an important prerequisite for the correct application and interpretation of diffusion-weighted MRI.
