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Localized factors relating to differential limb growth may play a larger role in the distribution and density of osteocyte lacunae than previously thought, and are potentially biasing the interpretations of analyses based on single samplings of isolated specimens.
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Multiplicity of testing with 47 biomarkers in an individual sample also has unique statistical challenges in the imputation of missing data and interpretation of analyses.
Combining populations that may show some genetic structure violates an assumption of the models underlying the coalescent techniques used in these programs; however, this is often a reasonable step to facilitate computation and interpretation of analyses [66].
Interpretation of analyses: EB, LJ, KR.
TG, PG, BW participated in the design of the study, and interpretation of analyses and data.
Morphological appraisal of specimens, intellectual contributions, and interpretation of analyses were given by SvN.
SC participated in study design and assisted with interpretation of analyses.
CWB participated in study design, provided oversight for sample collection, and assisted with interpretation of analyses.
KMB participated in study design, conducted all statistical analyses, participated in interpretation of analyses, and drafted the manuscript.
Another limitation is the reduced number of children with lead measurements, limiting interpretation of analyses controlling for lead exposure.
DGL provided modifications of study design, review and interpretation of analyses and made revisions to the manuscript.
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