Sensitivity and specificity of image interpretation were calculated along with their 95%% confidence intervals by pooling all of the interpretations performed in the assessment phase of the study.
The proportion of total activity (fitness) of the ribozyme attributable to the benefit of interpretation is calculated as follows.
The inter-observer variability of x-ray interpretations was calculated using the kappa coefficient [ 26] measuring the amount of agreement that is above random chance.
Interpretations were calculated comparing the penicillin + erythromycin killing effect versus penicillin or erythromycin rates tested alone.
All assays were performed according to the manufacturer's instructions and results (Panbio Units) and final interpretations were calculated (i.e., dengue or JEV positive, negative, or inconclusive) as per the prescribed method.
The distribution of children with hemodynamically significant CHD among interpretation groups was calculated as the respective numbers and proportions.
The Chi-square test was used for qualitative variables, two-tailed Student's paired t-test was used for quantitative variables and Relative Risk (RR) was calculated for interpretation.
Overall, an average mortality rate of 10.5/100,000 was calculated, but interpretation should be with caution due to the heterogeneity of studies.
The corrected optical density (COD) level was calculated before interpretation of the results by subtracting the optical density (OD) for the control antigen from sample OD (OD sample - OD control = COD).
The corrected optical density (COD) level was calculated before interpretation of the results by subtracting the mean OD for negative controls from sample OD (OD sample - mean OD negative = COD).
