Based on a conservative interpretation of this study, we took a proportion of 30% in our study.
Moderate-to-high degree of inconsistency/heterogeneity was observed which puts some caution for the interpretation of this study.
The interpretation of this study has several potential limitations.
However, an alternate interpretation of this study is that Cdc45 and MCMs might have been initially functioning at distal sites (e.g., at the streptavidin site itself) from where replisomes were functioning on the plasmid, and the streptavidin caused replisomes to accumulate at this site, which then overlapped some of the Cdc45 and MCM complexes (i.e., they caught up with one another).
There are important caveats on the interpretation of this study.
In the interpretation of this study some limitations are acknowledged.
There are several limitations to the interpretation of this study.
Several factors limit the interpretation of this study.
KJY, MPK, RSJ, and KHM participated in the design, coordination, and interpretation of this study.
Given the very low N, and evidence of toxicity, interpretation of this study is challenging.
A number of future studies should be conducted to strengthen the interpretation of this study.
