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These observations indicate that some SNPs in dbSNP are truly phenotypically mutational, and the interpretation of their functional consequences should be based on the context of carriers in the general population (or specific populations in case of founder mutations), or in the context of the phenotypic impact of the mutant molecule (for example, drug metabolism).
Third, the vast majority (over 90%) of associated variants have been found to localize outside of known protein-coding sequences, thus impeding the direct interpretation of their functional effects 11.
Typically, previous attempts to infer structure function relationships in the human brain have used tractography to identify pathways connecting anatomically defined regions, followed by post hoc interpretation of their functional significance based on previously published functional data.
In Table 4 we give an overview of these hub genes including their gene identifiers and a selected GO term in order to facilitate the interpretation of their functional context.
Differentiation of the SLF from the arcuate fasciculus and their respective cortical projections (see Glasser and Rillig [ 2008] for a meta-analysis) is not easily achieved by the current means of diffusion tensor imaging and interpretation of their functional roles must, therefore, await further empirical support.
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This is motivated by that biclusters which substantially overlap do not differ much in terms of their functional interpretation.
These trailblazing publications set evolutionary biologists to work re-evaluating their interpretation of the functional impact of the plateaus in the forces of natural selection which follow their decline [ 19, 20].
Therefore, the obtained results can be the basis of the interpretation of the functional properties of proteins characterizing their activity related to their conformational changes [11].
These responses were separated into different pathways/biochemical processes to aid interpretation and discussion of their potential functional effects and biological relevance.
In their guidelines for the interpretation of lung functional tests, ATS/ERS supports using the LLN at the 5th percentile of the frequency distribution of a reference "healthy" population as the cut-off value [ 68].
Interpretation of a functional neuroimaging study deals with select topics such as reverse inference and the ethical implications of study interpretation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com