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GG advised on the use and interpretation of the GRADE system.
The terminology adopted by the GRADE working group [ 16] for quality of evidence (high, moderate, low, very low) was used (see Table 2 for an interpretation of the GRADE categories).
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BPSs with imprecisely defined grading criteria have two important contributors to the errors of the scores: (1) the ability of the rater to make the estimate; and (2) the rater's interpretation of the BPS grading scale.
However, 70% of patients in that series did not have a staging bone scan, and there is evidence of systematic upgrading in the interpretation of the Gleason grading system over time (Smith et al, 2002; Kondylis et al, 2003).
Outcome variables were recorded per procedure for patient-reported pain scales, validated outcome measurement tools including the American Orthopaedic Foot and Ankle Score (AOFAS) and Ankle Osteoarthritis Score (AOS), radiographic progression per surgeon interpretation of the Kellgren Lawrence (K/L) grade, reoperation/re-treatment rates, and complication rates.
Men who had had hormone therapy before diagnostic biopsy were also excluded, because of the influence of hormone treatment in the interpretation of Gleason grade (Cuzick et al, 2006).
VW and JK graded 3 studies using Chiou's criteria in order to reach consensus on the interpretation of the criteria, and VW graded the remaining papers.
The interpretation of the ICC values was graded using the classification scheme of Munro, as low (0.26 0.49), moderate (0.50 0.69), high (0.70 0.89) and very high (0.90 1.00) [ 23].
However, considering the multiple factors involved in cTnT elevation, interpretation of low grade cTnT elevation in a COPD population should be done with caution.
The case reports also highlight a potential diagnostic pitfall in immunohistochemical interpretation of high grade prostate carcinomas with these four traditional antibodies.
Apparently the interpretation of the images by a visual grading scale is predominantly subjective.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com