For interpretation of "progression-free survival" as "currency," it was possible to evaluate the marginal rate of substitution in relation to the other risk attributes.
Nevertheless, the study by Byrski and colleagues is an open-label single-arm study of only 20 patients, with no central radiological confirmation of response rates, and both this study design and this size make a meaningful interpretation of progression-free survival very difficult.
Variability in automated static perimetry in glaucomatous visual field loss can cause mis-interpretation of progression of glaucoma [ 14, 15].
CaNoPy also identifies key milestones for study participants in their interpretation of disease progression.
The CLL003 results presented here demonstrate the power of cloneHD to quantify the subclonal evolution and the subclone genotypes from a WGS data set, facilitating the interpretation of tumor progression under a variable drug regimen.
Supporting Valid Interpretations of Learning Progression Level Diagnoses.
The need for such expertise is mandatory, given the considerable variability of histopathological phenotypes, which might result in "over-interpretation" of tumor progression leading to erroneous use of more aggressive therapeutic measures, even though most LEATs tend to have a very modest clinical behavior in the long run without bold risk of recurrence or malignant transformation [ 53].
From Figs. 1 and 2, it can be observed that changing to a sharper kernel between visits could lead to false interpretations of disease progression in a longitudinal study where reconstruction settings may vary over time; for example, if scanner models and imaging software are replaced by new models.
These problems include poor interobserver reproducibility of dysplasia interpretation and inconsistent rates of progression as well as regression of dysplasia, both of which have made it difficult to develop national surveillance guidelines (Rana and Johnston, 2000; Conio et al. 2003; Reid et al. 2000).
Participants' interpretations of symptoms and speed of progression of the illness influenced the steps undertaken to deal with the abnormal bodily experiences.
