The chromosome complement in a tumor sample can profoundly affect the interpretation of losses and gains within the karyotype, and conventional CGH using comparative hybridization between tumor and normal samples does not evaluate this variable.
The examples below show that interpretation of CN loss based solely upon log ratios may be misleading, especially in cases of apparent whole-chromosome loss.
The loss of cranial kinesis in Andalgalornis and other large-bodied phorusrhacids is a remarkable derived character, but the interpretation of this loss is complicated by persistent uncertainties about the functional role of cranial kinesis [10], [34].
Somatosensory evoked potentials (SSEPs) monitor global spinal cord function, and the interpretation of motor loss is based on inferred rather than direct measurements.
This interpretation of defective loss sensitivity in the gifted adolescents might account for the stereotypical portrayal of emotional maladaptation of gifted adolescents as compared to average adolescents [13], [14].
However, the interpretation of the loss of cAMP activity is unclear because the Q453E mutation would be predicted not to change the number of hydrogen bond with cAMP and thus the activity.
In addition, the evaluation and interpretation of cartilage loss depends on the surgeon's scale, experience, and familiarity with MRI.
Interpretation of mud losses, daily flow rate, PI, PLT and other data suggest that sector 1N and partially sector 4 are highly fractured.
Clearly, correct interpretation of such loss-of-function experiments, at such complex loci, requires careful consideration of potentially confounding factors.
This example underlines the need for caution in interpretation of putative losses suggested by genome sequences from individual species.
This indicates that sequencing AZFc in different haplogroups may yield crucial information on the evolution and functional specialization of amplicon gene copies and that clinical use of SFVs requires previous characterization of the sequence conversion profiles present in the sampled population to avoid erroneous interpretation of variant losses.
