The field has pursued the idea that Aβ accumulation is the central cause of AD based in part on an amyloid-centric interpretation of the genetics.
In sum, a valid, but inconvenient interpretation of AD genetics is that the aberrant processing of APP, or of other proteins cleaved by presenilin containing enzymes, is the key contributing factor in familial AD, rather than solely aberrant production of Aβ that contributes to histopathology.
YJC, BCL, JSK made conception and study design, SHJ carried out array-CGH, CNV detection, SNP genotyping and genomic qPCR validation, SHY, and TMK carried out CNV determination and data interpretation of molecular genetics studies, HJO, JEP, MJK, and GAK carried out sample collection and genomic qPCR validation analyses, YJC and SHJ analyzed the whole data, YJC, BCL, SHJ and SHY wrote the paper.
Our aim was to use both molecular genetics and functional studies to ensure correct interpretation of the genetic tests.
(3) Differences between and among population groups can be critically important for the design and interpretation of studies in genetics.
BJ and FG have been involved in the interpretation of data in genetics and ecophysiology, respectively.
Students also interpret the results of genetics experiments involving all four species and consider their interpretations in light of a phylogeny of the four species.
There was more uncertainty around both the interpretation, and communication and management of genetics report 2 in comparison to report 1.
The interpretation of LH in population genetics is usually disregarded.
