Online decision aid [ 43], although widely used, does not incorporate HER2 status and suffers from difficulties in interpretation of the co-morbidity index, which may significantly impact on the interpretation of benefit when compared to overall and not just cancer mortality risks.
Discrepancies may be due to heterogeneous interpretations of "benefit" from disease amelioration to cure.
While this may be unrealistic, we believe it provides a framework for interpretation of the benefits of the therapies of interest that is not confounded by assumptions regarding the sequence of subsequent therapies that patients might receive and their efficacy in this context.
Therefore, we changed the checklist item to include the concepts of results matching interpretations and of benefits being balanced with harms Item 23 (registration)—We added a new item on trial registration.
The interpretation of net benefit is the model with the highest net benefit should be chosen.
The authors believe that the strategy of grouping countermeasures according to both their aim and their timely application could simplify the computation and interpretation of cost-benefit analyses.
A high-quality trial may alter the interpretation of the benefit of the two treatment modalities.
We have presented direct evidence of therapy effects, extending the interpretation of treatment benefit beyond the previously reported clinical markers.
As such, we believe that interpretation of the benefit of PMRT should be limited to patients with fewer than 10 dissected lymph nodes.
38 Thus, taking into account the fact that studies of low methodological quality in which the estimate of quality is incorporated into the meta-analyses can alter the interpretation of the benefit of the intervention, 38 this meta-analysis has a major strength in that it separately considered the effect of treatment among high quality and low quality trials.
