For example, ABT-737's apparent affinity was 4-fold lower for Bcl-2, while 50-fold higher for Bcl-w, when using a BID-peptide compared with using a BIM-peptide., Therefore interpretations of affinity data for Bcl-2 SMIs should be taken with a grain of salt.
Structural interpretation of the affinity improvement was performed based on the crystal structure of the original prion binder in complex with the BoPrP (95 104) peptide by modeling the corresponding mutations.
Although previous molecular phylogenetic hypotheses conflicted with the traditional interpretation of cnidarian affinity for Polypodium, the molecular evidence we present, using an augmented dataset, ultimately confirms and reconciles this traditional hypothesis and suggests that Polypodium is indeed a cnidarian.
The composition of the OCG and the evolutionary interpretation of the affinity graph depend on the choice of function used to build the OCG; ideally the graph should capture all significant vertical and lateral evolutionary relationships that exist in a set of genomes.
The obtained knowledge about possible spatial distributions of the sugar epitopes exposed on the investigated hyperbranched neoglycoconjugates is detailed for all examples and forms important information for the interpretation and prediction of affinity data, which can be deduced from biological testing of these multivalent neoglycoconjugates.
Although the complexity of the system ruled out a numerical interpretation of the trimer affinity, it was clear that the FRET efficiency decreased more dramatically with the increase in the SDS concentration for CLAcrBW13C/P223G.
The interpretation of the receptor affinity-dependent binding is complex and depends, as described earlier, on the G protein-dependent affinity state of the GPCRs (Fig. 3C).
Results: A 2-dimensional six-domain model of the transporter based on the structure of a phosphinate ACE inhibitor (SQ-29852) was constructed to facilitate interpretation of the competitor affinities.
An intensive molecular docking study to a rhodopsin-based homology model of the hA3 receptor was carried out to obtain a 'structure-based pharmacophore model' that proved to be helpful for the interpretation of the observed affinities of the new hA3 pyrazoloquinoline antagonists.
Interpretations of its affinities have differed; one proposal places it in a group known as Australosphenida with other Mesozoic tribosphenic mammals from the southern continents (Gondwana) as well as the monotremes, while others favor closer affinities with northern (Laurasian) tribosphenic mammals or specifically with placentals.
