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The definition of intermittent dosing strongly affects interpretation of adherence.
The absence of a common reporting standard undermines interpretation of adherence patterns, product effectiveness, and predictors of adherence.
Therefore, we based our interpretation of adherence during the FL phase on changes in body weight and MetS criteria.
In conclusion, we found that while the definition of intermittent dosing has a strong effect on interpretation of adherence behavior, results confirm earlier qualitative findings and suggest that adherence interventions should address challenges related to sex work, mobility, and long-term PrEP.
Firstly, several unverified assumptions potentially limit the interpretation of adherence by using the medication possession ratio, i.e. that 1) patients are actually taking drugs every time they refill their medications 2) patients do not receive medication outside the hospital pharmacy network; and 3) the MPR threshold of 0.8 is a valid threshold for adherence.
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In our case, they provide a meaningful interpretation of the adherence of the treated nanolayer for withstanding conventional mechanical manipulations.
One interpretation of this finding is that unequal assessment of adherence between the adherent and the non adherent patients may have introduced bias in our estimates.
An alternative interpretation of the high level of adherence is that Hawthorne effects may have occurred, whereby the act of study participation improved motivation and thus increased adherence in both groups [ 26, 28, 30].
The results are presented as individual cases, followed by interpretation of the results and adherence to guidelines according to the SCORE and ESC scoring systems.
The latter interpretation requires agreement on the level of adherence to the TGC protocol in terms of timing of glucose measurements and insulin provision to qualify a patient as being on TGC.
The limited data on INR use may also have an impact on the interpretation of treatment pattern results, particularly adherence to anticoagulants, where changes in dosing are dependent on the results of laboratory monitoring.
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